# Thinking # Thinking # Responding This systematic review evaluated the prevalence of post-traumatic stress disorder (PTSD) in recipients of solid organ transplants (SOT), focusing on heart, lung, kidney, and liver transplants. A total of 28 studies involving 4,566 adult recipients were included after a comprehensive search of six major databases, with data extracted and assessed for quality using JBI critical appraisal checklists. The meta-analysis revealed an overall PTSD prevalence of 6% among SOT recipients, with considerable variability across organ types: prevalence was highest in heart transplant recipients (11%), followed by lung recipients (10%), kidney recipients (4%), and liver recipients (1%). The heterogeneity of PTSD prevalence across studies was significant (I² > 80%), likely due to differences in study designs, PTSD assessment methods (structured interviews vs. self-rating questionnaires), and recipient demographics. Psychological outcomes varied by organ type, reflecting the unique pre- and post-transplant challenges faced by recipients. Heart and lung recipients, who often endure life-threatening conditions and complex recovery processes, had higher rates of PTSD, while kidney and liver recipients showed lower prevalence, potentially due to shorter recovery periods and fewer complications. Differences in psychological assessment methods also influenced the findings, with studies using DSM-based criteria (e.g., DSM-III, DSM-IV) or various PTSD screening tools like the IES-R. This review highlights the need for standardized PTSD evaluation, routine psychological monitoring, and mental health support integrated into post-transplant care to improve recipients’ quality of life and long-term outcomes. Future research should focus on longitudinal studies, underrepresented groups (e.g., pediatric patients), and the impact of cultural and healthcare differences on psychological outcomes.